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KMID : 0043320110340060887
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Archives of Pharmacal Research
2011 Volume.34 No. 6 p.887 ~ p.891
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Synthesis, characterization, and antihyperglycemic activity of novel oxazolidine derivatives
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Selvam Theivendren Panneer
Kumar Palanirajan Vijayaraj
Ramu Parthasarathi
Kumar Arumugam Siva
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Abstract
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A number of compounds have been prepared in order to improve pharmacological roles of antihyperglycemic activity. In the present paper, a series of 3-benzyl-2-(4′-substituted phenyl)-4(5H)-(4″-nitrophenyl amino)-1,3-oxazolidines (6a?e) were tested against hyperglycemia. Their antihyperglycemic activity was evaluated by streptozotocin (STZ) and sucrose-loaded (SLM) models. Compounds 6a, b, c, d, and e displayed significant reductions in blood glucose in the streptozotocin and sucrose loaded rat models. The purity of the synthesized compounds was characterized by means of IR, 1H-NMR, mass spectral and elemental analysis.
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KEYWORD
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Oxazolidine, Aromatic aldehydes substitution, Antihyperglycemic activity
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